Prediction of Tyrosine Sulfated Sites in Integrins

Student Name: Allan Zhou

UCD Department: Neurobiology, Physiology, and Behavior

UCD Mentor: Dr. Grace Rosenquist

Tyrosine sulfation is a post-translational modification of proteins that is important to protein-protein interactions. We show that integrins, a family of trans-membrane receptors found in animals that link cells to the Extracellular Matrix, have a high number of likely tyrosine sulfation sites. Particularly, likely tyrosine sites in integrins are often found near ligand binding or recognition sites. Our data also show a high degree of conservation between likely sulfated tyrosine sites, suggesting their functional importance to the integrin.